| Asante Blackk | Kevin Richardson (Teen) |
| Caleel Harris | Antron McCray (Teen) |
| Ethan Herisse | Yusef Salaam (Teen) |
| Jharrel Jerome | Korey Wise |
| Marquis Rodriguez | Raymond Santana Jr (Teen) |
| Marsha Stephanie Blake | Linda McCray |
| Kylie Bunbury | Angie Richardson |
| Aunjanue Ellis | Sharonne Salaam |
| Vera Farmiga | Elizabeth Lederer |
| Felicity Huffman | Linda Fairstein |
| John Leguizamo | Raymond Santana Sr. |
| Niecy Nash | Deloris Wise |
| Michael Kenneth Williams | Bobby McCray |
| Len Cariou | DA Robert Morgenthau |
| Omar J. Dorsey | Elombre Brath |
| Chris Jackson | Peter Rivera |
| Joshua Jackson | Mickey Joseph |
| William Sadler | Detective Michael Sheehan |
| Blair Underwood | Bobby Burns |
| Suzzanne Douglas | Grace Cuffee |
| Chukwudi Iwuji | Colin Moore |
| Adepero Oduye | Nomsa Brath |
| Alexandra Templer | Trisha Meili |
| Allan Greenberg | Howard Diller |
| Alex Breaux | Tim Clements |
| Richard Bekins | Judge Galligan |
| Jayce Bartok | Detective Hildebrandt |
| Frank Pando | Detective Gonzalez |
| Edward Carnevale | Court Clerk |
| Kate Easton | Patricia Dean |
| Todd Lawson | John Loughlin |
| Juri Henley-Cohn | Dr. Kurtz |
| Walker Hare | Agent Adams |
| Caroline Hewitt | Local News Reporter |
| Denia Brache | Natividad |
| Pernell Walker | Gina Smith |
| Kris Arnold | Reporter |
| Joseph Adams | NY Post Editor |
| Reggie Alvin Green | Black Supporter |
| Christine Spang | Latina Newscaster |
| Kym Gomes | Juror 1 |
| Doug Barron | Juror 2 |
| Robert G. McKay | Juror 3 |
| Leigh DeLollis | Juror 4 |
| Ben Jacoby | White Male Newscaster 2 |
| Luis Avila | Drug Dealer |
| Henry Hunter Hall | Jermain |
| Donald Trump | Self |
| Kingsley Yeboah | Nation of Islam Member |
| Rick Zahn | White Print Reporter |
| Jaleesa Capri | Woman with Toddler |
| Andrew Mauney | White Male Newscaster |
| Christina Uniqe Castellanos | Parent |