| Kyle MacLachlan | Dale Cooper |
| Leslie Berger | New Mexico Wife |
| Robert Broski | Woodsman |
| Cullen Douglas | Disc Jockey |
| Erica Eynon | Experiment |
| Tikaeni Faircrest | Girl (1956) |
| George Griffith | Ray Monroe |
| Tad Griffith | New Mexico Husband |
| Sheryl Lee | Laura Palmer
(credit only) |
| Xolo Maridueña | Boy (1956)
(as Xolo Mariduena) |
| Joy Nash | Senorita Dido |
| Tracy Phillips | Receptionist |
| Frank Silva | Bob
(archive footage) |
| J.R. Starr | MC
(as JR Starr) |
| Carel Struycken | ??????? |
| Trent Reznor | 'The' Nine Inch Nails |
| Atticus Ross | 'The' Nine Inch Nails |
| Mariqueen Maandig | 'The' Nine Inch Nails
(as Mariqueen Maandig Reznor) |
| Robin Finck | 'The' Nine Inch Nails |
| Alessandro Cortini | 'The' Nine Inch Nails |
| Joey Castillo | 'The' Nine Inch Nails |
| Anthony Marcacci | Black Lodge Woodsman |
| Jon-Thomas Butler | Black Lodge Woodsman
(uncredited) |
| Christian Calloway | Black Lodge Woodsman
(uncredited) |
| Lindsay Lane | Bang Bang Waitress
(uncredited) |
| David Nieker | Black Lodge Woodsman
(uncredited) |
| Alex Reyme | Bang Bang Bar Patron
(uncredited) |
| Stewart Strauss | Black Lodge Woodsman
(uncredited) |