| Kyle MacLachlan | Dale Cooper |
| Mädchen Amick | Shelly Briggs |
| Tammie Baird | Lorraine |
| Ronnie Gene Blevins | Tommy |
| Juan Carlos Cantu | Officer Reynaldo |
| Candy Clark | Doris Truman |
| Lisa Coronado | Hit and Run Mom |
| Jeremy Davies | Jimmy |
| Laura Dern | Diane Evans |
| Josh Fadem | Phil Bisby |
| Eamon Farren | Richard Horne |
| Miguel Ferrer | FBI Agent Albert Rosenfield |
| Patrick Fischler | Duncan Todd |
| Robert Forster | Sheriff Frank Truman |
| Pierce Gagnon | Sonny Jim Jones |
| Hailey Gates | Drugged-out Mother |
| Balthazar Getty | Red |
| James Grixoni | Deputy Jesse Holcomb |
| Andrea Hays | Heidi |
| Michael Horse | Deputy Chief Tommy 'Hawk' Hill |
| Jay Jee | Patrol Officer |
| Sheryl Lee | Laura Palmer |
| Jeremy Lindholm | Mickey |
| Sarah Jean Long | Miriam Sullivan |
| David Lynch | FBI Deputy Director Gordon Cole |
| Don Murray | Bushnell Mullins |
| John Pirruccello | Deputy Chad Broxford |
| Hunter Sanchez | Hit and Run Boy |
| Tom Sizemore | Anthony Sinclair |
| Harry Dean Stanton | Carl Rodd |
| Al Strobel | Phillip Gerard |
| Jodi Thelen | Maggie |
| Naomi Watts | Janey-E Jones |
| Nafessa Williams | Jade |
| Christophe Zajac-Denek | Ike 'The Spike' Stadtler |
| Sharon Van Etten | Sharon Van Etten |
| Carolyn Pennypacker Riggs | Sharon Van Etten |
| John Phillip Iron | Sharon Van Etten |
| Zeke Hutchins | Sharon Van Etten |
| Ime Etuk | Red's bodyguard |
| Sarah Yarborough | Young Couple |