| Milo Ventimiglia | Jack Pearson |
| Mandy Moore | Rebecca Pearson |
| Sterling K. Brown | Randall Pearson |
| Chrissy Metz | Kate Pearson |
| Justin Hartley | Kevin Pearson |
| Susan Kelechi Watson | Beth Pearson |
| Chris Sullivan | Toby Damon |
| Jon Huertas | Miguel Rivas |
| Alexandra Breckenridge | Sophie |
| Niles Fitch | 17 Year Old Randall |
| Logan Shroyer | 17 Year Old Kevin |
| Hannah Zeile | 17 Year Old Kate |
| Mackenzie Hancsicsak | 10 Year Old Kate |
| Parker Bates | 10 Year Old Kevin |
| Lonnie Chavis | 10 Year Old Randall |
| Eris Baker | Tess Pearson |
| Faithe Herman | Annie Pearson |
| Ron Cephas Jones | William Hill |
| Jermel Nakia | Young William |
| Lyric Ross | Déjà |
| Joy Brunson | Shauna |
| Iantha Richardson | Essex County Social Worker |
| Debra Jo Rupp | Linda |
| Chris V. Pipkin | Keith |
| Chad Chambers | Fred |
| Patrick Cage | James |
| Larry VanBuren Jr. | Craig |
| Craig Stepp | Pat |
| Jonny Berryman | Little Boy |
| Sydnee Parker Anderson | 1 Year Old Kate |
| Marisol Correa | Howard University Business Student |
| Emily Eaglin | Howard Student |
| Preslaysa Edwards | College Student |
| Ceasar Romero Evans Jr. | Birthday Kid |
| Krystian Alexander Lyttle | Shauna's Neighbor |
| Tiana Melvina | Howard University College Student |
| Cadence Murray | Singing Birthday girl |
| Destiney Richardson | University Student |
| Kelsey Saunders | Howard University Business Student |
| Brandon Singleton | College Student |
| Roger Tyler | 1997 Howard College Student |