| Dominic West | Off. James 'Jimmy' McNulty |
| John Doman | Dep. Comm. for Operations William A. Rawls |
| Frankie Faison | Commissioner Ervin H. Burrell |
| Aidan Gillen | Mayor Thomas 'Tommy' Carcetti |
| Deirdre Lovejoy | Asst. State's Atty. Rhonda Pearlman |
| Clarke Peters | Det. Lester Freamon |
| Wendell Pierce | Det. William 'Bunk' Moreland |
| Lance Reddick | Col. Cedric Daniels |
| Andre Royo | Reginald 'Bubbles' Cousins |
| Sonja Sohn | Det. Shakima 'Kima' Greggs |
| Jim True-Frost | Roland 'Prez' Pryzbylewski |
| Robert Wisdom | Howard 'Bunny' Colvin |
| Seth Gilliam | Det. Ellis Carver |
| Domenick Lombardozzi | Sgt. Thomas 'Herc' Hauk |
| Reg E. Cathey | Norman Wilson |
| Chad L. Coleman | Dennis 'Cutty' Wise |
| Jamie Hector | Marlo Stanfield |
| Glynn Turman | Former Mayor Clarence V. Royce |
| J.D. Williams | Preston 'Bodie' Broadus |
| Michael Kenneth Williams | Omar Little |
| Corey Parker Robinson | Det. Leander Sydnor |
| Jermaine Crawford | Duquan 'Dukie' Weems |
| Maestro Harrell | Randy Wagstaff |
| Julito McCullum | Namond Brice |
| Tristan Mack Wilds | Michael Lee |
| Gbenga Akinnagbe | Chris Partlow |
| Neal Huff | Chief of Staff Michael Steintorf |
| Robert F. Chew | Joseph 'Proposition Joe' Stewart |
| Anwan Glover | Slim Charles |
| Method Man | Melvin 'Cheese' Wagstaff |
| Benjamin Busch | Off. Anthony Colicchio |
| Boris McGiver | Lt. Charles Marimow |
| Delaney Williams | Sgt. Jay Landsman |
| Marlyne Barrett | Council President Nerese Campbell |
| S. Robert Morgan | Butchie |
| Ramon Rodriguez | Renaldo |
| Shamika Cotton | Raylene Lee |
| Stacie Davis | Ms. Duquette |
| Susan Duvall | Assistant Principal Marcia Donnelly |
| Denise Hart | Miss Anna Jeffries |
| Robert Ehrlich | Security Guard |
| David E. Goodman | Budget Director |
| Rick Otto | Off. Kenneth Dozerman |
| Frederick Strother | State Delegate Odell Watkins |
| Melvin Williams | Deacon |
| Nathan Corbett | Donut |
| Thuliso Dingwall | Kenard |
| Chynna Gray | Woman |
| Sandi McCree | De'Londa Brice |
| Felicia Pearson | Felicia 'Snoop' Pearson |
| Davon Cooper | Darnell Tyson |
| Taylor King | Zenobia Dawson |
| Jeffrey Lorenzo | Karim Williams |
| Rakiya Orange | Charlene Young |
| Gene Terinoni | Lt. Jimmy Asher |
| Devin Tweedy | Man |
| Kelli R. Brown | Kimmy |
| Dan De Luca | David Parenti |
| Yolanda Gaskins | School Board Representative |
| Rashad Orange | Sherrod |
| Richard Welchel | Man |
| Michael Willis | Andy Krawczyk |
| Michael Ahl | Detective |
| Larry Andrews | Donnie |
| Darrell Britt-Gibson | Darius 'O-Dog' Hill |
| Carl Clemons | Cheese's Muscle |
| David DeBoy | Detective Shea |
| Hyi Y. Lim | Convenience Store Owner |
| John Lim | ER Doctor |
| Kwame Patterson | 'Monk' Metcalf |
| Derrick Purvey | Big Guy |