| Dominic West | Det. James 'Jimmy' McNulty |
| John Doman | Dep. Comm. for Operations William A. Rawls |
| Idris Elba | Russell 'Stringer' Bell |
| Frankie Faison | Acting Commissioner Ervin H. Burrell |
| Aidan Gillen | Councilman Thomas 'Tommy' Carcetti |
| Wood Harris | Avon Barksdale |
| Deirdre Lovejoy | Asst. State's Atty. Rhonda Pearlman |
| Clarke Peters | Det. Lester Freamon |
| Wendell Pierce | Det. William 'Bunk' Moreland |
| Lance Reddick | Lt. Cedric Daniels |
| Andre Royo | Reginald 'Bubbles' Cousins |
| Sonja Sohn | Det. Shakima 'Kima' Greggs |
| Jim True-Frost | Det. Roland 'Prez' Pryzbylewski |
| Robert Wisdom | Maj. Howard 'Bunny' Colvin |
| Seth Gilliam | Sgt. Ellis Carver |
| Domenick Lombardozzi | Det. Thomas 'Herc' Hauk |
| J.D. Williams | Preston 'Bodie' Broadus |
| Michael Kenneth Williams | Omar Little |
| Corey Parker Robinson | Det. Leander Sydnor |
| Glynn Turman | Mayor Clarence V. Royce |
| Chad L. Coleman | Dennis 'Cutty' Wise |
| Jamie Hector | Marlo Stanfield |
| Brandy Burre | Theresa D'Agostino |
| Melanie Nicholls-King | Cheryl |
| Delaney Williams | Sgt. Jay Landsman |
| Leo Fitzpatrick | Johnny Weeks |
| S. Robert Morgan | Butchie |
| Melvin Williams | Deacon |
| Megan Anderson | Jen Carcetti |
| Shamyl Brown | Donette |
| Jay Landsman | Lt. Dennis Mello |
| Richard Burton | Sean 'Shamrock' McGinty |
| Tray Chaney | Malik 'Poot' Carr |
| Anwan Glover | Slim Charles |
| Benjamin Busch | Off. Anthony Colicchio |
| Mia Arnice Chambers | Squeak |
| Melvin Jackson Jr. | Bernard |
| Ryan Sands | Off. Lloyd 'Truck' Garrick |
| De'Rodd Hearns | Herbert De'Rodd 'Puddin' Johnson |
| Michael Kostroff | Maurice 'Maury' Levy |
| Felicia Pearson | Felicia 'Snoop' Pearson |
| Rico Whelchel | Rico |
| Gbenga Akinnagbe | Chris Partlow |
| R. Emery Bright | Community Relations Sgt. |
| Eugene R. Little | Cutty's Boss |
| Cleo Reginald Pizana | Chief of Staff Coleman Parker |
| Vicki Jean Clark | Woman in Street |
| Richard DeAngelis | Col. Raymond Foerster |
| Robert X. Golphin | Crackhead |
| Joilet Harris | Off. Caroline Massey |
| Tamara Johnson | Lieut. Cindy Lowry |
| James Lewis | Politician |
| Rick Otto | Off. Kenneth Dozerman |
| Thomas W. Stewart | Man In Street |
| Gregory L. Williams | Det. Michael Crutchfield |