| Alan Alda | Senator Arnold Vinick |
| Kristin Chenoweth | Annabeth Schott |
| Allison Janney | C.J. Cregg |
| Joshua Malina | Will Bailey |
| Mary McCormack | Kate Harper |
| Janel Moloney | Donna Moss |
| John Spencer | Leo McGarry |
| Bradley Whitford | Josh Lyman |
| Jimmy Smits | Matthew Santos |
| Martin Sheen | President Josiah Bartlet |
| Ron Silver | Bruno Gianelli |
| Patricia Richardson | Sheila Brooks |
| Lily Tomlin | Deborah Fiderer |
| Brett Cullen | Governor Ray Sullivan R-WV |
| Stephen Root | Bob Mayer |
| Ron Canada | Under Secretary of State Theodore Barrow |
| Steve Ryan | Secretary of Defense Miles Hutchinson |
| Dean Norris | Steve Hodder - Republican Party Chairman |
| Matthew Del Negro | Bram Howard |
| Karis Campbell | Ronna |
| Diana Maria Riva | Edie Ortega |
| Ramon De Ocampo | Otto |
| J. Patrick McCormack | General Jimmy Wendall |
| Melinda McGraw | Jane Braun |
| Melissa Fitzgerald | Carol Fitzpatrick |
| Annie Morgan | Annie |
| John L. Curtis | Vinick Aide |
| Robert Aguilar Jr. | Marine Guard |
| Daniel Doble | Secret Service Agent |
| Chris Kerner | Police Officer #3 |
| James McMann | Secret Service Agent |
| Brian Tarbox | Police Officer |