| Alan Alda | Senator Arnold Vinick |
| Kristin Chenoweth | Annabeth Schott |
| Dulé Hill | Charlie Young |
| Allison Janney | C.J. Cregg |
| Mary McCormack | Kate Harper |
| Richard Schiff | Toby Ziegler |
| John Spencer | Leo McGarry |
| Bradley Whitford | Josh Lyman |
| Jimmy Smits | Matthew Santos |
| Martin Sheen | President Josiah Bartlet |
| Janeane Garofalo | Louise Thornton |
| Lily Tomlin | Deborah Fiderer |
| Mitch Pileggi | Senator Dresden |
| John Aylward | Barry Goodwin - Former DNC Chair |
| Steve Ryan | Secretary of Defense Miles Hutchinson |
| Tom Everett | Agent Charles Frost |
| NiCole Robinson | Margaret Hooper |
| Renée Estevez | Nancy |
| Karis Campbell | Ronna |
| Evan Arnold | Ned |
| Thomas Kopache | Assistant Secretary of State Bob Slatterly |
| Tom Chick | National Reporter Gordon
(as Tom W. Chick) |
| Trev Broudy | Local Reporter |
| Melanie Chapman | Michelle Banks - Teacher |
| James Schendel | Father |
| David Q. Combs | Clifford Reynolds - Teacher |
| Joyce Guy | Charlayne - Reporter #1 |
| David Brownstein | Reporter #2 |
| Kerstin Lindquist | Anchor |
| Kathy Goral | Santos Campaign Donor
(uncredited) |
| Makram Khoury | Chairman Nizar Farad
(uncredited) |
| Sean King | Santos Supporter
(uncredited) |
| Abigail Kintanar | Matthew Santos Supporter
(uncredited) |
| Michael Shiraef | Santos Aide
(uncredited) |