| Alan Alda | Senator Arnold Vinick |
| Stockard Channing | Abbey Bartlet |
| Dulé Hill | Charlie Young |
| Allison Janney | C.J. Cregg |
| Joshua Malina | Will Bailey |
| Mary McCormack | Kate Harper |
| Janel Moloney | Donna Moss |
| Richard Schiff | Toby Ziegler |
| John Spencer | Leo McGarry |
| Bradley Whitford | Josh Lyman |
| Jimmy Smits | Matthew Santos |
| Martin Sheen | President Josiah Bartlet |
| Kristin Chenoweth | Annabeth Schott |
| Gary Cole | Vice President Bob Russell |
| Teri Polo | Helen Santos |
| Ed O'Neill | Governor Eric Baker D-PA |
| Elisabeth Moss | Zoey Bartlet |
| Sam Robards | Greg Brock |
| Steve Ryan | Secretary of Defense Miles Hutchinson |
| Brett Cullen | Governor Ray Sullivan R-WV |
| Mark L. Taylor | DNC Chairman Steve Rorsche |
| Tim Kelleher | Dylan Clark |
| Renée Estevez | Nancy |
| Karis Campbell | Ronna |
| Mindy Seeger | Chris |
| Charles Noland | Steve |
| Joyce Guy | Charlayne |
| David St. James | Congressman Darren Gibson, R-MI |
| Matt McKenzie | Republican Convention Speaker #2 |
| Nancy Linari | Convention Speaker #3 |
| David Grant Wright | NASA Administrator Edwin Kelwick |
| Jerry Buys | Secret Service Agent |
| John David Denison | Secret Service Agent |