| Stockard Channing | Abbey Bartlet |
| Dulé Hill | Charlie Young |
| Allison Janney | C.J. Cregg |
| Joshua Malina | Will Bailey |
| Mary McCormack | Kate Harper |
| Janel Moloney | Donna Moss |
| Richard Schiff | Toby Ziegler |
| John Spencer | Leo McGarry |
| Bradley Whitford | Josh Lyman |
| Jimmy Smits | Matthew Santos |
| Martin Sheen | President Josiah Bartlet |
| Kristin Chenoweth | Annabeth Schott |
| Gary Cole | Vice President Bob Russell |
| Mary Kay Place | Surgeon General Millicent Griffith |
| Ron Canada | Under Secretary of State Theodore Barrow |
| NiCole Robinson | Margaret Hooper |
| Patrick Fischler | Walter Sprout |
| Cleo King | Marla Worisky |
| Melissa Fitzgerald | Carol Fitzpatrick |
| Kim Webster | Ginger |
| Ben Murray | Curtis Carruthers |
| William Hootkins | U.S. Translator |
| Willie Gault | Secret Service Agent |
| David Grant Wright | NASA Administrator Edwin Kelwick |
| Raymond Ma | Chinese President Lian |
| James Kyson | Chinese Translator Zheng |
| Ping Wu | Chinese Official |
| Jonathan Brent | White House Photographer |
| Janette Kim | News Reporter #1 |
| James McMann | Press |
| Ken Weiner | Dr. Stremlowe |