| Stockard Channing | Abbey Bartlet |
| Dulé Hill | Charlie Young |
| Allison Janney | C.J. Cregg |
| Joshua Malina | Will Bailey |
| Mary McCormack | Kate Harper |
| Janel Moloney | Donna Moss
(credit only) |
| Richard Schiff | Toby Ziegler |
| John Spencer | Leo McGarry |
| Bradley Whitford | Josh Lyman |
| Martin Sheen | President Josiah Bartlet |
| Armin Mueller-Stahl | Israeli Prime Minister Efraim 'Eli' Zahavy |
| Makram Khoury | Palestinian Chairman Nizar Farad
(as Makram J. Khoury) |
| Lily Tomlin | Deborah Fiderer |
| Terry O'Quinn | General Nicholas Alexander |
| Steven Culp | Speaker of the House Jeff Haffley |
| NiCole Robinson | Margaret Hooper |
| Natalija Nogulich | Israeli Ambassador Shira Galit |
| Marcelo Tubert | Palestinian Prime Minister Saeb Mukarat |
| Eli Danker | Israeli Defense Minister Doran Mazar |
| Melissa Fitzgerald | Carol Fitzpatrick |
| Kris Murphy | Katie Witt |
| Ann Ducati | Maya Zahavy |
| Lawrence Cameron Steele | Garner
(as Cameron Steele) |
| Wadi Sadellah | Prayer Leader |
| Kahil Dotay | Palistinian Prayer #2
(uncredited) |
| Nanci Hernandez-Hall | White House Aide
(uncredited) |
| Michael Wingate Jones | Navy Steward
(uncredited) |
| Daniel Mandehr | Israeli Diplomat
(uncredited) |
| Jay Viera | Camp David Staffer
(uncredited) |