| Stockard Channing | Abbey Bartlet |
| Dulé Hill | Charlie Young |
| Allison Janney | C.J. Cregg |
| Joshua Malina | Will Bailey |
| Mary McCormack | Kate Harper |
| Janel Moloney | Donna Moss |
| Richard Schiff | Toby Ziegler |
| John Spencer | Leo McGarry |
| Bradley Whitford | Josh Lyman |
| Martin Sheen | President Josiah Bartlet |
| Armin Mueller-Stahl | Israeli Prime Minister Efraim 'Eli' Zahavy |
| Jason Isaacs | Colin Ayres |
| Lily Tomlin | Deborah Fiderer |
| Terry O'Quinn | General Nicholas Alexander |
| Steven Culp | Speaker of the House Jeff Haffley |
| NiCole Robinson | Margaret Hooper |
| Natalija Nogulich | Israeli Ambassador Shira Galit |
| Michael Kagan | FBI Director George Arnold |
| Marcelo Tubert | Palestinian Prime Minister Saeb Mukarat |
| Eli Danker | Israeli Defense Minister Doran Mazar |
| Tim Lounibos | Colonel Leahy |
| Charlotte Colavin | Representative Sheila Fields |
| Melissa Fitzgerald | Carol Fitzpatrick |
| Mindy Seeger | Chris |
| Tom Chick | Reporter Gordon |
| Novella Nelson | Gail Fitzwallace |
| Ann Ducati | Maya Zahavy |
| Anneliza Scott | Second Nurse |
| Leesa Severyn | ATF Anchor |
| Warren Sweeney | Taylor Reid |
| Makram Khoury | Palestinian Chairman Nizar Farad |
| Towanda Underdue | White House Staffer |