| Stockard Channing | Abbey Bartlet |
| Dulé Hill | Charlie Young |
| Allison Janney | C.J. Cregg |
| Joshua Malina | Will Bailey |
| Janel Moloney | Donna Moss |
| Richard Schiff | Toby Ziegler |
| John Spencer | Leo McGarry |
| Bradley Whitford | Josh Lyman |
| Martin Sheen | President Josiah Bartlet |
| Mary McCormack | Kate Harper |
| Gary Cole | Vice President Bob Russell |
| Jason Isaacs | Colin Ayres |
| Gerald McRaney | USAF Gen. Alan Adamle |
| Lily Tomlin | Deborah Fiderer |
| Steven Culp | Speaker of the House Jeff Haffley |
| Ron Canada | Under Secretary of State Theodore Barrow |
| Steve Ryan | Secretary of Defense Miles Hutchinson |
| Natalija Nogulich | Israeli Ambassador Shira Galit |
| Renée Estevez | Nancy |
| Navid Negahban | Maz |
| Tim Lounibos | Colonel Leahy |
| Marcelo Tubert | Palestinian Prime Minister Saeb Mukarat |
| Melissa Fitzgerald | Carol Fitzpatrick |
| Mindy Seeger | Chris |
| Ron Ostrow | Reporter John |
| Ben Siegler | Reporter George |
| Sonya Leslie | Nurse Parnes |
| Di Koob | Nurse Rinier |
| Hira Ambrosino | Commentator #1 |
| John Colella | Commentator #2 |
| Doug Hale | Anchor |
| Endre Hules | Maitre D' |
| Jake Mailey | Commentator #3 |
| John Hartmann | Floor Manager |
| Dave McGowan | Stadium Announcer |
| John Doty | Secret Service Agent
(uncredited) |
| Makram Khoury | Palestinian Chairman Nizar Farad
(uncredited) |