| Stockard Channing | Abbey Bartlet |
| Dulé Hill | Charlie Young |
| Allison Janney | C.J. Cregg |
| Joshua Malina | Will Bailey |
| Janel Moloney | Donna Moss |
| Richard Schiff | Toby Ziegler |
| John Spencer | Leo McGarry |
| Bradley Whitford | Josh Lyman |
| Martin Sheen | President Josiah Bartlet |
| Mary McCormack | Kate Harper |
| Lily Tomlin | Deborah Fiderer |
| Michael O'Neill | Secret Service Agent Ron Butterfield |
| Reed Diamond | Dr. Mike Gordon |
| Wilson Cruz | Jack Sosa |
| Brent Huff | Agt. Broder |
| Beau Billingslea | Agent Velasquez |
| Tracey Costello | Agent Moody |
| Jamison Yang | Agent Lee |
| Melette Le Blanc-Cabot | Nurse |
| Markus Alexander | Secret Service
(uncredited) |
| Jerry Buys | Secret Service Agent
(uncredited) |