| Stockard Channing | Abbey Bartlet |
| Dulé Hill | Charlie Young |
| Allison Janney | C.J. Cregg |
| Joshua Malina | Will Bailey |
| Janel Moloney | Donna Moss |
| Richard Schiff | Toby Ziegler |
| John Spencer | Leo McGarry |
| Bradley Whitford | Josh Lyman |
| Martin Sheen | President Josiah Bartlet |
| Gary Cole | Vice President Bob Russell |
| Lily Tomlin | Deborah Fiderer |
| Nina Siemaszko | Ellie Bartlet |
| Melissa Marsala | Rina |
| Brian Kerwin | Ben Dryer |
| Michael Gaston | Eric Hayden |
| Deirdre Lovejoy | Lisa Wolfe |
| NiCole Robinson | Margaret Hooper |
| John Lafayette | Dr. Louis Foy |
| Cherry Jones | Barbara Layton |
| Melissa Fitzgerald | Carol Fitzpatrick |
| Caroll Spinney | Big Bird |
| Kevin Clash | Elmo
(voice) |
| Fran Brill | Zoe |
| Carmen Osbahr | Rosita |
| Joey Mazzarino | Muppet Doctor
(as Joseph Mazzarino) |
| Alice Dinnean | Rosita's Right Hand
(as Alice Dinnean Vernon) |
| Paul McGinnis | Elmo's Right Hand |
| Penny Griego | Anchor |
| Anthony Giangrande | Gary |
| Doug Tompos | Bentley's Aide |
| Ivan Allen | News Anchor Roger Salier
(uncredited) |
| Anne Lockhart | White House Staff
(uncredited) |