| Dulé Hill | Charlie Young |
| Allison Janney | C.J. Cregg |
| Joshua Malina | Will Bailey |
| Janel Moloney | Donna Moss |
| Richard Schiff | Toby Ziegler |
| John Spencer | Leo McGarry |
| Bradley Whitford | Josh Lyman |
| Martin Sheen | President Josiah Bartlet |
| Armin Mueller-Stahl | Israeli Prime Minister Efraim 'Eli' Zahavy |
| Gary Cole | Vice President Bob Russell |
| Jay Mohr | Taylor Reid |
| Anna Deavere Smith | Nancy McNally |
| Terry O'Quinn | General Nicholas Alexander |
| Steve Ryan | Secretary of Defense Miles Hutchinson |
| Christina Chang | Alex Moreau |
| Renée Estevez | Nancy |
| Thomas Kopache | Assistant Secretary of State Bob Slatterly |
| Ryan Cutrona | CIA Director George Rollie |
| Christopher Maher | Iranian Ambassador |
| Melissa Fitzgerald | Carol Fitzpatrick |
| Randy Brooks | Lyle |
| Charles Noland | Reporter Steve |
| David Bickford | NASA Official |
| Ginger Justin | Swiss Diplomat |
| Robert Aguilar Jr. | Marine Guard |
| Jerry Buys | Secret Service Agent |
| Austin MacDonald | Boy Who Meets the President |