| Stockard Channing | Abbey Bartlet |
| Dulé Hill | Charlie Young |
| Allison Janney | C.J. Cregg |
| Joshua Malina | Will Bailey |
| Janel Moloney | Donna Moss |
| Richard Schiff | Toby Ziegler |
| John Spencer | Leo McGarry |
| Bradley Whitford | Josh Lyman |
| Martin Sheen | President Josiah Bartlet |
| Mary-Louise Parker | Amy Gardner |
| John Amos | Percy Fitzwallace |
| Taye Diggs | Secret Service Agent Wesley |
| Michael O'Neill | Secret Service Agent Ron Butterfield |
| Anna Deavere Smith | Nancy McNally |
| Clark Gregg | FBI Special Agent Michael Casper |
| Harry Groener | Secretary of Agriculture Roger Tribbey |
| NiCole Robinson | Margaret Hooper |
| Trent Ford | Jean Paul |
| Alan Dale | Secretary of Commerce Mitch Bryce |
| Vernee Watson | Nurse |
| J. Patrick McCormack | General Jimmy Wendall |
| Melissa Fitzgerald | Carol Fitzpatrick |
| Kim Webster | Ginger |
| Devika Parikh | Bonnie |
| Laura Gardner | Gwen |
| Kris Murphy | Katie Witt |
| Timothy Davis-Reed | Mark O'Donnell |
| Charles Noland | Reporter Steve |
| Randy Brooks | Arthur Leeds |
| Susanne Filkins | Geri |
| Shay Bennett | Peggy |
| Lucy Butler | Jill |
| Lance E. Nichols | Jay |
| Milt Tarver | Jerry |
| Jon Van Ness | Andrew |
| Dan Manning | Agent Banks |
| John Antonini | Jamie Reed |
| Shannon Marshall | Randy Weathers |
| Gary Telles | FBI Agent #1 |
| Kathryn Klvana | FBI Agent #2 |
| Weston Blakesley | Dr. Wellman |
| Brady Rubin | Judge |
| Haskell V. Anderson III | Interior Secretary |
| Estuardo Rodriguez Minano | Paramedic |
| Ivan Allen | News Anchor Roger Salier |
| Keely Jones | Reporter |
| Diane Badger | Cabinet Member |
| Jim Gabriel | Cabinet Member |
| Lizz Robbins | Club Patron |
| Robert Aguilar Jr. | Marine Guard |
| Stephen Alexander | Secret Service Agent Pitt |
| Jerry Buys | Secret Service Agent |
| Emilio Estevez | Young Jed Bartlet |
| John Goodman | Glenallen Walken |
| Zeljko Ivanek | Steve Atwood |
| Al Sotto | FBI Agent |
| Katie Whicker | White House Assistant |