| Rob Lowe | Sam Seaborn |
| Stockard Channing | Abbey Bartlet |
| Dulé Hill | Charlie Young |
| Allison Janney | C.J. Cregg |
| Janel Moloney | Donna Moss |
| Richard Schiff | Toby Ziegler |
| John Spencer | Leo McGarry |
| Bradley Whitford | Josh Lyman |
| Martin Sheen | President Josiah Bartlet |
| Hal Holbrook | Asst. Secretary of State Albie Duncan |
| James Brolin | Governor Robert Ritchie, R-FL |
| Joshua Malina | Will Bailey |
| Kathleen York | Andrea Wyatt |
| Joanna Gleason | Atty. Jordon Kendall |
| NiCole Robinson | Margaret Hooper |
| Danica McKellar | Elsie Snuffin |
| Tony Amendola | Qumari U.N. Ambassador Ali Nissir |
| John Aniston | Alexander Thompson |
| Ashleigh Olden | Sharon |
| Paige Orr | Karen |
| Trent Trail | Lawrence |
| Martinez Evelina | Staffer
(as Tomiko Martinez) |
| Amy Bruckner | Sally |
| Gia Cross | Girl |
| Ashley Benson | Girl |
| Alison Robertson | Carrie |
| Jason McCune | Jonathan |
| Ted Davis | Bobby |
| Michael Raysses | Ted Willard |
| Stephanie Venditto | June Wheeler |
| Anita Dashiell | Reporter Jo |
| Ross Shimabuku | Derek |
| Mary Beth McDonough | Beth
(as Mary McDonough) |
| Nick Jameson | Chet |
| Scott Facher | Stage Manager |
| Kim Webster | Ginger |
| Timothy Davis-Reed | Mark O'Donnell |
| Melissa Fitzgerald | Carol Fitzpatrick |
| Kris Murphy | Katie Witt |
| Amy Parks | Bartender Tammy |
| Stacy Reed Payton | Girl in Bar
(as Stacy Reed) |
| Steve Stapenhorst | Martin |
| Tim Van Pelt | Congressman Harry |
| George Coe | Senator Howard Stackhouse
(uncredited) |
| Michelle Hotaling | President Bartlett's Daughter
(uncredited) |
| Robert Paul Lewis | San Diego Police Officer
(uncredited) |
| Tim Matheson | Vice President John Hoynes
(uncredited) |