| Rob Lowe | Sam Seaborn |
| Dulé Hill | Charlie Young |
| Allison Janney | C.J. Cregg |
| Janel Moloney | Donna Moss |
| Richard Schiff | Toby Ziegler |
| John Spencer | Leo McGarry |
| Bradley Whitford | Josh Lyman |
| Martin Sheen | President Josiah Bartlet |
| Mary-Louise Parker | Amy Gardner |
| Clark Gregg | FBI Special Agent Michael Casper |
| George Coe | Sen. Howard Stackhouse |
| Malachi Throne | Israeli Foreign Minister Ben Yosef |
| Deborah May | Janet |
| Robin Bartlett | Susan Thomas |
| Andrew McFarlane | Anthony Marcus |
| John Cothran | Civilian Advisor
(as John Cothran Jr.) |
| NiCole Robinson | Margaret Hooper |
| Larry Brandenburg | Senator Michael Jackson |
| Kim Webster | Ginger |
| Hilary Angelo | Emily
(as Hilary Salvatore) |
| Kris Murphy | Katie Witt |
| Becky Meister | Reporter Sally |
| Ralph Meyering Jr. | Civilian Tom |
| Richard Green | Jerry |
| Lynn Tufeld | Grace |
| Joe Marinelli | Morris |
| Brandon Noll | Staffer |
| Joe Cosgrove | Cardinal |
| Noel Conlon | Jason Weaver |
| Helen Duffy | Senator White |
| Jerry Buys | Secret Service Agent
(uncredited) |
| Dale Hawes | Secret Service Agent
(uncredited) |
| Barrett Rakestraw | Reporter
(uncredited) |