| Rob Lowe | Sam Seaborn |
| Dulé Hill | Charlie Young |
| Allison Janney | C.J. Cregg |
| Janel Moloney | Donna Moss |
| Richard Schiff | Toby Ziegler |
| John Spencer | Leo McGarry |
| Bradley Whitford | Josh Lyman |
| Martin Sheen | President Josiah Bartlet |
| Adam Arkin | Dr. Stanley Keyworth |
| Mary-Louise Parker | Amy Gardner |
| Mark Harmon | Agent Simon Donovan |
| Lily Tomlin | Deborah Fiderer |
| James Brolin | Governor Robert Ritchie, R-FL |
| John Amos | Percy Fitzwallace |
| Kurt Fuller | SitRoom Civilian Advisor |
| Michael O'Neill | Secret Service Agent Ron Butterfield |
| David Huddleston | Sen. Max Lobell, R |
| Armin Shimerman | Richard III |
| NiCole Robinson | Margaret Hooper |
| Renée Estevez | Nancy |
| Andrew McFarlane | Anthony, Simon Donovan's 'Little Brother' |
| William Thomas Jr. | SitRoom Civilian Advisor David |
| Fred Sanders | Ted |
| Glenn Morshower | Mike Chysler |
| Thomas Kopache | Assistant Secretary of State Bob Slatterly |
| Wren T. Brown | 'No' Vote Man |
| Ken Thorley | 'No' Vote Man |
| Basil Hoffman | Congressman |
| Melissa Fitzgerald | Carol Fitzpatrick |
| Qaid Al-Nomani | Qumari Def. Min. Prince Abdul Shareef |
| Nasser Faris | Qumari Translator |
| John David Conti | Howell |
| Nate Reese | Cantwell |
| Paul Norwood | Bristol |
| Randy Brooks | Arthur Leeds |
| Mindy Seeger | Chris |
| Kris Murphy | Katie Witt |
| Timothy Davis-Reed | Mark O'Donnell |
| Charles Noland | Reporter Steve |
| S.E. Perry | Marine Officer |
| Heidi Anderson-Swan | Waitress |
| William Dennis Hunt | Duke of York |
| Jeanie Hackett | Queen Margaret |
| Orlando Seale | Young Clifford |
| Douglas Weston | Bedford |
| Adrian Diamond | Young Boy |
| Joshua Wolf Coleman | Chorus |
| Charles Currier | Chorus |
| Russell Edge | Chorus |
| Joshua Fardon | Chorus |
| Richard Gould | Chorus |
| Rob Nagle | Chorus |
| Kevin Owers | Chorus |
| Graham Shiels | Chorus |
| Richard Soto | Chorus |
| Glenn Kubota | Korean Grocer |
| Karen Tsen Lee | Reporter |
| Ted Koch | Reporter |
| Mark Gerald Douglas | Secret Service Agent in NYC |
| Lisa Datz | Agent |
| James Villani | Thug |
| Danny Downey | Thug #2 |
| Sean Allen Jones | Uniformed Secret Service Agent |