| Rob Lowe | Sam Seaborn |
| Dulé Hill | Charlie Young |
| Allison Janney | C.J. Cregg |
| Janel Moloney | Donna Moss |
| Richard Schiff | Toby Ziegler |
| John Spencer | Leo McGarry |
| Bradley Whitford | Josh Lyman |
| Martin Sheen | President Josiah Bartlet |
| Mark Harmon | Agent Simon Donovan |
| Ian McShane | Russian Negotiator Nikolai Ivanovich |
| John Amos | Percy Fitzwallace |
| Peter Scolari | Antares C.E.O. Jake Kimball |
| Michael O'Neill | Secret Service Agent Ron Butterfield |
| Gregory Itzin | State Dept. Representative |
| Bill Cobbs | Alan Tatum |
| Svetlana Efremova | Ludmila Koss, Novaya Gazeta |
| George Tasudis | Russian Negotiator George Kazlovsky |
| Renée Estevez | Nancy |
| Melissa Fitzgerald | Carol Fitzpatrick |
| Valarie Pettiford | White House Security Guard Janice |
| Damien Leake | Dr. Ted Tatum |
| Timothy Davis-Reed | Mark O'Donnell |
| Mindy Seeger | Chris |
| Charles Noland | Reporter Steve |
| Kris Murphy | Katie Witt |
| Jeff Mooring | Reporter Phil |
| Kim Webster | Ginger |
| Lee Faranda | Aide |
| Elizabeth Liang | Staffer |
| Sean Allen Jones | Uniformed Secret Service Agent |
| Troy Martin | NSA Translator |