| Rob Lowe | Sam Seaborn |
| Dulé Hill | Charlie Young |
| Allison Janney | C.J. Cregg |
| Janel Moloney | Donna Moss |
| Richard Schiff | Toby Ziegler |
| John Spencer | Leo McGarry |
| Bradley Whitford | Josh Lyman |
| Martin Sheen | President Josiah Bartlet |
| Adam Arkin | Dr. Stanley Keyworth |
| Emily Procter | Ainsley Hayes |
| Kathleen York | Andrea Wyatt |
| NiCole Robinson | Margaret Hooper |
| Alanna Ubach | Celia Walton |
| Carmen Argenziano | Leonard Wallace, Billy Price's Editor |
| Nancy Cassaro | Janet Price |
| Basil Wallace | McKonnen Loboko |
| Paul Fitzgerald | Casey Reed, CapitalScoop.com |
| Kim Webster | Ginger |
| Devika Parikh | Bonnie |
| Timothy Davis-Reed | Mark O'Donnell |
| Kris Murphy | Katie Witt |
| Sean Allen Jones | Uniformed Secret Service Agent
(uncredited) |