| Rob Lowe | Sam Seaborn |
| Dulé Hill | Charlie Young |
| Allison Janney | C.J. Cregg |
| Janel Moloney | Donna Moss |
| Richard Schiff | Toby Ziegler |
| John Spencer | Leo McGarry |
| Bradley Whitford | Josh Lyman |
| Martin Sheen | President Josiah Bartlet |
| Stockard Channing | Abbey Bartlet |
| Anna Deavere Smith | Nancy McNally |
| Kirsten Nelson | Young Mrs. Dolores Landingham |
| Jason Widener | Young Jed Bartlet |
| Don McManus | Greg Summerhays |
| NiCole Robinson | Margaret Hooper |
| Lawrence O'Donnell | Dr. Bartlet
(as Lawrence O'Donnell Jr.) |
| Gregory Alan Williams | Robbie Mosley
(as Gregalan Williams) |
| John Bennett Perry | Bill Wakefield |
| Kathryn Joosten | Dolores Landingham |
| Fred Ornstein | Congressman Harry Wade |
| Bill Gratton | Advisor #1 |
| Melissa Fitzgerald | Carol Fitzpatrick |
| Devika Parikh | Bonnie |
| William Duffy | Larry |
| Peter James Smith | Ed |
| Kim Webster | Ginger |
| Patrick Thomas O'Brien | Hanson |
| Christopher Murray | Tony Phillips |
| Shelley Malil | Renfro |
| Angelo Tiffe | Greenway |
| Jane Lynch | Reporter in Briefing Room |
| Charles Noland | Reporter Steve |
| E.E. Bell | Advisor #2 |
| Robert A. Becker | Minister Monohan |
| Trevor Eddy | Young Bartlet's Friend |
| Doris E. McMillon | Reporter Sandy
(as Doris McMillon) |
| Ivan Allen | News Anchor Roger Salier |
| Lewis Grenville | Reporter |
| Wendy Poole | Staffer |
| Michael Ahl | Air Force Major General
(uncredited) |
| Chelsea Bond | Reporter
(uncredited) |
| Brian Dragonuk | Mourner at Cathedral
(uncredited) |
| Sean Allen Jones | Uniformed Secret Service Agent
(uncredited) |
| Christopher J. Marcinko | Third Reporter
(uncredited) |
| Andrellos Mitchell | Funeral Mourner
(uncredited) |