| Rob Lowe | Sam Seaborn |
| Dulé Hill | Charlie Young |
| Allison Janney | C.J. Cregg |
| Janel Moloney | Donna Moss |
| Richard Schiff | Toby Ziegler |
| John Spencer | Leo McGarry |
| Bradley Whitford | Josh Lyman |
| Martin Sheen | President Josiah Bartlet |
| Stockard Channing | Abbey Bartlet |
| Timothy Busfield | Danny Concannon |
| Tim Matheson | Vice President John Hoynes |
| Elisabeth Moss | Zoey Bartlet |
| Michael O'Neill | Secret Service Agent Ron Butterfield |
| Jorja Fox | Secret Service Agent Gina Toscano |
| Anna Deavere Smith | Nancy McNally |
| Kathryn Joosten | Dolores Landingham |
| NiCole Robinson | Margaret Hooper |
| Daniel von Bargen | Air Force General Ken Shannon |
| Michael Bryan French | Hospital Administrator |
| Pamela Gordon | Woman in Bar |
| Andy Umberger | Cal Mathis |
| Jim Ortlieb | Dr. Keller |
| Peter White | Mr. Gage |
| Ernie Lively | Mr. Loch |
| Jody Wood | Mr. Cameron |
| Melissa Fitzgerald | Carol Fitzpatrick |
| Kim Webster | Ginger |
| Kris Murphy | Katie |
| Mindy Seeger | Chris |
| Randy Brooks | Arthur |
| Ivan Allen | TV Anchor |
| Willie Gault | Agent Madsen |
| Elijah Mahar | Agent Dixon |
| Dafidd McCracken | Agent #1 |
| Juan A. Riojas | Agent #2 |
| Bradley James | Agent #3 |
| Al Twanmo | Agent Cho |
| Derek Coleman | Agent #4 |
| Ming Lo | Dr. Lee |
| Rhonda Stubbins White | Dr. Whitaker |
| Sean Moran | Dr. Holbrook |
| Carol Kiernan | Doctor |
| Dan Gunther | Doctor #1 |
| Maria Maestas McCann | Nurse |
| Trisha Simmons | Nurse Debbie |
| Ted Garcia | TV Reporter |
| David Ursin | Bartender |
| Matt Gottlieb | Military Aide |
| Thomas Spencer | Aide #3 |
| Andy Milder | Senator's Aide |
| Robyn Pedretti | Senator's Aide |
| Gary Carlos Cervantes | Civilian Advisor |
| Victor McCay | Peter |
| Kat Sawyer | Sam's Secretary |
| V. Kim Blish | Volleyball Player |
| Scott Parrott | Paramedic #1 |
| Sunita Koshy | Paramedic #2 |
| Shawn D. Woodyard | Paramedic #3 |
| Chad McKnight | Paramedic #4 |
| Tanya Linette Smith | Paramedic #5 |
| Kivi Rogers | Paramedic #6 |
| Gary Hershberger | Jerry |
| Peter Birkenhead | Steven |
| Jane Lynch | Reporter |
| Jerry Sroka | Reporter |
| Jenny Buchanan | Questioner |
| Harris Laskawy | Questioner #2 |
| Alex Baik | Secret Serviceman |
| Denise Dowse | Nurse 1 |
| Brian Dragonuk | NBC Video Cameraman |
| Christopher Francis | Passenger |
| Paul Moncrief | Staffer |