| Nicole Kidman | Grace Fraser |
| Hugh Grant | Jonathan Fraser |
| Edgar Ramírez | Detective Joe Mendoza |
| Noah Jupe | Henry Fraser |
| Lily Rabe | Sylvia Steineitz |
| Matilda De Angelis | Elena Alves |
| Edan Alexander | Miguel Alves |
| Annaleigh Ashford | Alexis Young |
| Fala Chen | Jolene McCall |
| Tarik Davis | Michael Hoffman |
| Michael Devine | Detective Paul O'Rourke |
| Maria Dizzia | Diane Porter |
| Vedette Lim | Amanda Emory |
| Janel Moloney | Sally Maybury |
| Matt McGrath | Joseph Hoffman |
| Jeremy Shamos | Robert Connaver |
| Jason Kravits | Dr. Stuart Rosenfeld |
| Donald Sutherland | Franklin Reinhardt |
| Madeline Faye Santoriello | Sylvia's Daughter |
| Andrew Keenan-Bolger | Jason Reynolds |
| Naledi Murray | Shelby McGibbons |
| Irma-Estel LaGuerre | Franklin's Maid |
| Alana O'Brien | Natalie |
| Laura Sudduth | Jennifer |
| Sara Koviak | Kayla |
| Isabella Knight | Diner Waitress |
| Onika Day | Female Officer |
| Christian Steiner | TV Newscaster |
| Lee Garrett | TV Newscaster |
| Todd Zeile | TV Newscaster |
| Kendra Farn | TV Newscaster |
| Laurie Ann Crompton | News Reporter |
| Billy Lake | Franklin's Doorman |
| Mark Perrone | Franklin's Doorman |
| Lara Barbieri | Student |
| Dante DiGiorgio | Reardon School Kid |
| John DiGiorgio | Press |
| Jack Ronan Grindley | Reardon School Kid |
| Michael Iacono | Private School Kid |
| Jarrod LaBine | Reardon Parent |
| Reed Harlow-Grayce LaRocca | Student |
| Lynn Marocola | NYPD Officer |
| Watari Nishida | News Press |
| Victoria Rooney | Hospital Patient |
| Mylee Rose | Student |