| Michael Chiklis | Vic Mackey |
| Catherine Dent | Danni Sofer |
| Paula Garcés | Tina Hanlon
(as Paula Garces) |
| Walton Goggins | Shane Vendrell |
| Michael Jace | Julien Lowe |
| Jay Karnes | Holland Wagenbach |
| David Marciano | Steve Billings |
| Cathy Cahlin Ryan | Corrine Mackey |
| David Rees Snell | Ronnie Gardocki |
| CCH Pounder | Claudette Wyms |
| Laurie Holden | Agent Olivia Murray |
| F.J. Rio | Cruz Pezuela |
| Ludwig Manukian | Ellis Rezian |
| Hector Luis Bustamante | Luis Aramboles |
| Anna Maria Horsford | A.D.A. Beth Encardi |
| Nigel Gibbs | Assistant Chief Roy Phillips |
| William Charlton | Grubman |
| Mike Gomez | Nacio |
| Scoot McNairy | Doug Obermyer |
| Autumn Chiklis | Cassidy Mackey |
| Roderick Ikaika Maggay | Lil' BK |
| L. Michael Burt | Moses |
| Chaney Kley | Officer Asher |
| J. David Shanks | Officer Stamos |
| Zone | Jamal |
| Loretta Jean | Trinket |
| Loreni Delgado | Ana |
| Kikeasha Fisher | Girl |
| Felix Pabon | Enrique |
| Jessica Grace Orr | Female Guard
(as Jessica Orr) |
| Demond Robertson | Mike Jones, Esq |
| Christian E. Murphy | K-Swizz |
| Joshua Walker | Gangbanger |
| Betty Garcia Rainey | Mexican Woman |
| Jaime Alvarez | Pablo |
| Ruben Avitia | Background Detective
(uncredited) |