| John Turturro | John Stone |
| Riz Ahmed | Nasir 'Naz' Khan |
| Michael Kenneth Williams | Freddy Knight |
| Bill Camp | Dennis Box |
| Jeannie Berlin | Helen Weiss |
| Amara Karan | Chandra Kapoor |
| Payman Maadi | Salim Khan |
| Poorna Jagannathan | Safar Khan |
| Glenne Headly | Alison Crowe |
| Paul Sparks | Don Taylor |
| Sofia Black-D'Elia | Andrea Cornish |
| Glenn Fleshler | Judge Roth |
| Paulo Costanzo | Ray Halle |
| Don Harvey | Detective Tomalikis |
| Joseph Badalucco Jr. | Detective
(as Joe Badalucco) |
| J.D. Williams | Trevor Williams |
| Charlie Hudson III | Duane Reade |
| Esau Pritchett | Mr. Day |
| James L. Ward | Trial Bailiff
(as Jay Ward) |
| Michael J. Burg | Bar Owner |
| Robert C. Kirk | John O'Hara |
| Monette McKay | Court Stenographer |
| Bryan Burton | Shelter Volunteer |
| Charles Brice | Terry |
| Lord Jamar | Tino |
| Donnetta Lavinia Grays | Nurse |
| Michael Braun | Dr. Nelson |
| Fisher Stevens | Saul the Pharmacist |
| Roscoe Orman | Jury Foreman |
| Chris McKinney | Rikers Head CO |
| Syam M. Lafi | Hasan Khan
(as Syam Lafi) |
| Ariya Ghahramani | Amir Farik |
| Bam Bam | The Cat |
| Brooke Alexandra | Correctional Officer
(uncredited) |
| Reginald L. Barnes | Snake-Freddy's Crew #1
(uncredited) |
| Kristoffe Brodeur | Police Officer
(uncredited) |
| Chris Bryant | Freddy's Crew 'Blood'
(uncredited) |
| Xavier Cadeau | X
(uncredited) |
| David Chen | Inmate
(uncredited) |
| Coffey | Freddy's Crew Member
(uncredited) |
| Christofer Jirau | Tattooed Inmate
(uncredited) |
| Pedro Marcelino | Passerby
(uncredited) |
| Damany Mathis | Blood Inmate
(uncredited) |
| Moniere | Imam (Arabic Call to Prayer)
(uncredited) |
| Jesus Padilla | Inmate
(uncredited) |
| Adam Piacente | Courtroom Press
(uncredited) |
| Shaun Rey | Latin King Inmate
(uncredited) |
| Cruz Rodriguez | Child at Prison Visitation
(uncredited) |
| Samuel Standard | Freddie's Crew
(uncredited) |