| John Turturro | John Stone |
| Riz Ahmed | Nasir 'Naz' Khan |
| Michael Kenneth Williams | Freddy Knight |
| Bill Camp | Dennis Box |
| Jeannie Berlin | Helen Weiss |
| Amara Karan | Chandra Kapoor |
| Payman Maadi | Salim Khan |
| Poorna Jagannathan | Safar Khan |
| Chip Zien | Dr. Katz |
| Paulo Costanzo | Ray Halle |
| Paul Sparks | Don Taylor |
| Glenn Fleshler | Judge Roth |
| Mohammad Bakri | Tariq |
| Nabil Elouahabi | Yusuf |
| Jeff Wincott | Detective Lucas |
| Sofia Black-D'Elia | Andrea Cornish
(as Sofia Black D'Elia) |
| Frank Wood | Medical Examiner |
| Syam M. Lafi | Hasan Khan
(as Syam Lafi) |
| Pallavi Sastry | Khan's Neighbor |
| Victor Verhaeghe | CSI Turley |
| Daniel Gadi | Trainer |
| Trudie Styler | Jean Rothman |
| Clint Mauro | Jean's New Toy Boy |
| Ariya Ghahramani | Amir Farik |
| Aubrey Joseph | Dwight Gooden Stone
(as Aubrey Omari Joseph) |
| Aaron Moten | Petey |
| Mustafa Shakir | Victor |
| Monique Pappas | Petey's Mom |
| Andrew Stewart-Jones | Coach Harris |
| Hon Jen Two | Dr. Yee |
| Joe Egender | Cutty |
| Danny Flaherty | Copy Store Clerk |
| Don Harvey | Detective Tomalikis |
| James L. Ward | Trial Bailiff
(as Jay Ward) |
| J.D. Williams | Trevor Williams |
| Steven Randazzo | Andrea's Neighbor |
| Esau Pritchett | Mr. Day |
| Joseph Badalucco Jr. | Detective
(as Joe Badalucco) |
| Chris McKinney | Rikers Head CO |
| Brooke Alexandra | Correctional Officer
(uncredited) |
| Will Janowitz | Dr. Ross
(uncredited) |
| David Cheekz Weeks | Eddy - Inmate
(uncredited) |