| John Turturro | John Stone |
| Riz Ahmed | Nasir 'Naz' Khan |
| Michael Kenneth Williams | Freddy Knight |
| Bill Camp | Dennis Box |
| Jeannie Berlin | Helen Weiss |
| Payman Maadi | Salim Khan |
| Poorna Jagannathan | Safar Khan |
| Glenne Headly | Alison Crowe |
| Amara Karan | Chandra Kapoor |
| Afton Williamson | Wiggins |
| Sticky Fingaz | Rikers Inmate |
| Paul Sparks | Don Taylor |
| Mohammad Bakri | Tariq |
| Nabil Elouahabi | Yusuf |
| Pernell Walker | Rikers PO |
| Joshua Bitton | Maldonado |
| Chris Perfetti | Lawyer |
| Eleasha Gamble | Rikers Guard |
| Axel Avin Jr. | Rikers ID CO |
| Scott Menville | Rikers Latino Prisoner |
| Chris McKinney | Rikers Head CO |
| Lord Jamar | Tino |
| Albert Jones | District Attorney |
| Jeremy Shamos | Dermatologist |
| Michelle Duffy | Reporter |
| Nikiya Mathis | Rikers Check-in Assistant |
| Kymbali Craig | Rikers Strip Search Guard |
| Manny Perez | Inspector McCaffrey |
| Danny Henriquez | |
| Michael Rivera | Police Impound Lot Officer |
| Vincent Laresca | |
| Alexis Suarez | 87th Street Cop |
| Tom Coiner | Eczema Help Group Member |
| Bobby Di Cicco | Eczema Help Group Member |
| Michael Buscemi | Steve |
| Patch Darragh | Eczema Help Group Member |
| Sean Ringgold | Pound Employee |
| Bryan Burton | Shelter Volunteer |
| Reginald L. Barnes | Freddy's Crew #1 |
| Chris Bryant | Freddy's Crew 'Blood' |
| Xavier Cadeau | X |
| Heath Calvert | Press Conference Reporter |
| David Chen | Inmate |
| Frisco Cosme | Latin King Inmate |
| Ray Daniels | Inmate |
| Darryl Dwayne | Inmate |
| Christofer Jirau | Tattooed Inmate |
| Damany Mathis | Blood Inmate |
| Vladimir Merisca | District Attorney |
| Omar Salmon | Inmate 1 |
| Samuel Standard | Freddie's Crew |
| David Cheekz Weeks | Eddy - Inmate |