| John Turturro | John Stone |
| Riz Ahmed | Nasir 'Naz' Khan |
| Bill Camp | Dennis Box |
| Jeannie Berlin | Helen Weiss |
| Payman Maadi | Salim Khan |
| Poorna Jagannathan | Safar Khan |
| Paul Sparks | Don Taylor |
| Sofia Black-D'Elia | Andrea Cornish |
| Afton Williamson | Wiggins |
| Ben Shenkman | Sgt. Klein |
| Ned Eisenberg | Lawrence Felder |
| Nabil Elouahabi | Yusuf |
| Nicholas Turturro | Detective |
| Joshua Bitton | Maldonado |
| Jeff Wincott | Detective Lucas |
| Frank De Julio | Pauline |
| Syam M. Lafi | Hasan Khan
(as Syam Lafi) |
| Eddie Cooper | Mardon |
| Victor Verhaeghe | CSI Turley |
| Ray Abruzzo | Eddie |
| Frank Wood | Medical Examiner |
| Tijuana Ricks | Morgue Attendant |
| Russell G. Jones | Detective |
| Jonny Coyne | Detective Fitzroy |
| Carter Hudson | Attorney in Line |
| Jimmy Palumbo | 12th Precinct Cop #1 |
| Mike DiGiacinto | 12th Precinct Cop #2 |
| Joseph Latimore | Bailiff |
| Terron Jones | Tamar Gee |
| Adam LeFevre | Judge |
| Simon Feil | Gurwitz |
| Mike Figueroa | Officer Frank Hernandez |
| Donté Bonner | Bell
(as Donte Bonner) |
| Manny Perez | Inspector McCaffrey |
| Jordan Mahome | |
| Quincy Chad | Tombs Officer #1 |
| Jimmy Gary Jr. | Tombs Officer #2 |
| Omar Evans | |
| Andre Ware | Tombs Officer #3 |
| Saycon Sengbloh | Tombs Officer |
| Renoly Santiago | Tombs Junkie |
| Aubrey Joseph | Dwight Gooden Stone
(as Aubrey Omari Joseph) |
| LaChanze | Dwight's Mom |
| Don Guillory | ADA |
| Catherine A. Callahan | ADA Assistant |
| Anthony Mangano | |
| Cliff Moylan | Arraignment Bailiff |
| Nicholas J. Coleman | Detective McPherson
(as Nick Coleman) |
| Mohamed Alshami | Ortiz, F
(uncredited) |
| Xavier Cadeau | X
(uncredited) |
| David Chen | Inmate
(uncredited) |
| Frisco Cosme | Latin King Inmate
(uncredited) |
| Ray Daniels | Blood Gang Inmate
(uncredited) |
| Lashawn Garnes | Civilian behind John Stone in security line
(uncredited) |
| Steve Goffner | Public Defender
(uncredited) |
| Christofer Jirau | Tattooed Inmate
(uncredited) |
| Kevin Martinez Rivera | CSU Videographer
(uncredited) |
| Damany Mathis | Blood Inmate
(uncredited) |
| Thea McCartan | Reporter
(uncredited) |
| Shaun Rey | Latin King Inmate
(uncredited) |
| Frank Ridley | Jerry
(uncredited) |
| David Cheekz Weeks | Eddy - Inmate
(uncredited) |