| Jeff Daniels | Will McAvoy |
| Emily Mortimer | MacKenzie McHale |
| John Gallagher Jr. | Jim Harper |
| Alison Pill | Maggie Jordan |
| Thomas Sadoski | Don Keefer |
| Dev Patel | Neal Sampat |
| Olivia Munn | Sloan Sabbith |
| Sam Waterston | Charlie Skinner |
| David Harbour | Elliot Hirsch |
| Terry Crews | Lonny Church |
| Kelen Coleman | Lisa Lambert |
| Stephen McKinley Henderson | Solomon Hancock
(voice) |
| Christina Kirk | Flight Attendant |
| Natalie Morales | Kaylee |
| Salli Richardson-Whitfield | Jane Barrow |
| Adina Porter | Kendra James |
| Chris Chalk | Gary Cooper |
| Margaret Judson | Tess Westin |
| Wynn Everett | Tamara Hart |
| Thomas Matthews | Martin Stallworth |
| John F. Carpenter | Herb Wilson |
| Trieu Tran | Joey Phan |
| Charlie Weirauch | Jake Watson |
| Ashton Moio | Lester |
| David Douglas | Peter |
| Jeff Corbett | Captain Louis Embry |
| Mark Meir | East Room Reporter
(as Mark Scheibmeir) |
| Kahlil Garcia | Police Officer #2 |
| Bruno Amato | Officer Bello |
| Sergio Enrique | Police Officer |
| Ron Ostrow | Passenger #1 |
| Chase Kim | Passenger #2 |
| Reatha Grey | Passenger #3 |
| Jordana Capra | Passenger #4 |
| Jaimie Fauth | Passenger #5 |
| Marc Abbink | Airplane Passenger
(uncredited) |
| Wolf Blitzer | Self - On TV Monitor
(archive footage) (uncredited) |
| Dana Bonner | Newsroom Staff
(uncredited) |
| James Hamrick | Jesse
(uncredited) |
| Lucinda Lewis | NY Business Executive
(uncredited) |
| Barack Obama | Self
(archive footage) (uncredited) |
| Geraldo Rivera | Self
(archive footage) (uncredited) |
| Anna Sampson | Hipster
(uncredited) |