| Rachel Brosnahan | Miriam 'Midge' Maisel |
| Alex Borstein | Susie Myerson |
| Michael Zegen | Joel Maisel |
| Marin Hinkle | Rose Weissman |
| Kevin Pollak | Moishe Maisel |
| Tony Shalhoub | Abe Weissman |
| Zachary Levi | Benjamin |
| Luke Kirby | Lenny Bruce |
| Caroline Aaron | Shirley Maisel |
| Will Brill | Noah Weissman |
| Justine Lupe | Astrid Weissman |
| Brandon Uranowitz | Buzz Goldberg |
| Bryan Batt | Dr. Stone ('The Legend Of Lizzie') |
| Danny Burstein | Sewell ('The Legend Of Lizzie') |
| Laura Osnes | Lizzie ('The Legend Of Lizzie') |
| Bobby Steggert | Phipps ('The Legend Of Lizzie') |
| Jacob Kemp | Samuel |
| Misha Brooks | Bellboy #1 |
| Tony Macht | Bellboy #2 |
| John Weigand | Mel |
| Annie Meisels | Operator |
| Connor Ratliff | Chester |
| Christopher Manning | Kent |
| Lauren Blumenfeld | Gabi |
| Allison Strong | Talia Goldstein |
| Arielle Goldman | Eliana |
| Cheryl Stern | Ida |
| Barbara Malley | Goldie |
| Joanna Glushak | Mrs. O'Toole |
| Rick Crom | Jerome |
| Ben Graney | Robbie |
| Stephanie Rothenberg | Ruthie |
| Andrew Polk | Fred |
| Jill Abramovitz | Stevie |
| Chara Kirkland | Cocktail Waitress |
| Armand Reiser | Kitter |
| Peter Linari | Zundee |
| Peggy J. Scott | Verla |
| Joseph La Rocca | Howie |
| Lee Wilkof | Melvin |
| Lindsay Barrasse | Simon Says Dancer |
| Anthony Belfiore | Theatre Patron |
| Evan Chessari | Bar Patron |
| Chris DaBella | Resort Staff |
| Casey Marie Ecker | Bar Patron |
| Rachel Horwitz | Resort Staff |
| Laura Maselli | Comedy Club Patron |
| Christopher McIntyre | Deli Patron |
| Frank Murdocco | Concord Waiter |
| Giuseppe Virzi | Adam (Simon Says Kid) |
| Lauren Yaffe | Concord Patron |