| Clive Owen | Dr. John W. Thackery |
| André Holland | Dr. Algernon Edwards |
| Jeremy Bobb | Herman Barrow |
| Juliet Rylance | Cornelia Robertson |
| Eve Hewson | Nurse Lucy Elkins |
| Michael Angarano | Dr. Bertie Chickering Jr. |
| Chris Sullivan | Tom Cleary |
| Cara Seymour | Sister Harriet |
| Eric Johnson | Dr. Everett Gallinger |
| David Fierro | Inspector Jacob Speight |
| Maya Kazan | Eleanor Gallinger |
| Leon Addison Brown | Jesse Edwards |
| Grainger Hines | Captain August Robertson |
| LaTonya Borsay | Evaline Edwards
(as La Tonya Borsay) |
| Helen Coxe | Miss Carhart |
| Danny Hoch | Bunky Collier |
| Brian Kerwin | Corky Vanderbilt |
| Rachel Korine | Junia |
| Edwin Lugo | Ernesto Mendieta |
| Peter Maloney | Drunk Barber |
| Collin Meath | Phinny Sears |
| Frank Wood | Mr. Havershorn |
| Happy Anderson | Jimmy |
| Michael Berresse | Parke-Davis Representative |
| Lucas Papaelias | Eldon Pouncey |
| Richard James Porter | Monsignor Joseph Mills Lawlor |
| Suzanne Savoy | Victoria Robertson |
| Allen Warnock | Clarence Dally |
| Brittany Bellizeare | Millicent |
| Grant Chang | Mr. Sung |
| Caroline Clay | Miss Manx |
| Kevin T. Collins | Waiter |
| Ylfa Edelstein | Nurse Baker |
| Bonita Hamilton | Mrs. Gamble |
| Ryan Homchick | Orderly Schleif |
| Danya LaBelle | Mrs. Lefkowitz |
| Ghana Leigh | Miss Odom |
| Christopher Brian Roach | Collier's Man with Leg Injury |
| Kate Simmons | Alice |
| Jing Xu | Mrs. Sung |
| John Antorino | Immigrant Worker
(uncredited) |
| Francine Daveta | Evelyn
(uncredited) |
| Maria Mercedes Galuppo | Pedestrian
(uncredited) |
| Sean Harris | Footman
(uncredited) |
| Mara McCann | Protestor
(uncredited) |
| Booch O'Connell | Flower Vendor
(uncredited) |