| Karl Urban | Billy Butcher |
| Jack Quaid | Hughie Campbell |
| Antony Starr | Homelander |
| Erin Moriarty | Starlight |
| Dominique McElligott | Queen Maeve |
| Jessie T. Usher | A-Train |
| Laz Alonso | Mother's Milk |
| Chace Crawford | The Deep |
| Tomer Capone | Frenchie |
| Karen Fukuhara | Kimiko Miyashiro |
| Nathan Mitchell | Black Noir |
| Colby Minifie | Ashley Barrett |
| Aya Cash | Stormfront |
| Giancarlo Esposito | Stan Edgar |
| Shantel VanSanten | Becca Butcher |
| Ann Cusack | Donna January |
| Claudia Doumit | Victoria Neuman |
| Cameron Crovetti | Ryan |
| Laila Robins | Grace Mallory |
| Goran Visnjic | Alastair Adana |
| Jim Beaver | Secretary of Defense Robert A. Singer |
| Thomas Roberts | Thomas Roberts |
| Nneka Elliott | NNC News Anchor |
| Dan Duran | VNN News Anchor |
| J.D. Nicholsen | Sheriff Ed Flanagan |
| Okiki Kendall | Teacher |
| Ksenia Daniela Kharlamova | Girl in Classroom |
| Stephanie Jung | Samantha |
| Tabitha Tao | Assistant |
| Abbas Wahab | Alastair Adana's Assistant |
| Jarrod Terrell | Planet Vought Waiter |
| Stefan Lawrence | High End Restaurant Waiter |
| Toyin Sebastien Ajimati | Michel |
| Ian Kilburn | Vought Security Agent |
| Carlos Pinder | Tactical Team Leader |
| Cydney Penner | Jody |
| Liyou Abere | Janine |
| Farleena Khan | Tourist |
| Randal Baumer | Stormfront Fan |
| Vicki Kim | Stormfront Fan |
| Paul Rivers | Stormfront Fan |
| Sydney Coombs | Stormfront Fan |
| Chris River | Young Guy Fan |