| Dominic West | Noah Solloway |
| Ruth Wilson | Alison Bailey |
| Maura Tierney | Helen Solloway |
| Joshua Jackson | Cole Lockhart |
| Catalina Sandino Moreno | Luisa Leon |
| Omar Metwally | Dr. Vik Ullah |
| Julia Goldani Telles | Whitney Solloway |
| Jadon Sand | Trevor Solloway |
| Sanaa Lathan | Janelle Wilson |
| Emily Browning | Sierra |
| Mare Winningham | Cherry Lockhart |
| Deirdre O'Connell | Athena Bailey |
| Janel Moloney | Ariel |
| Zenobia Shroff | Priya Ullah |
| Max Fowler | Colin |
| Zuhair Haddad | Abdul Ullah |
| Darren Goldstein | Oscar Hodges |
| Linda Park | Dr. Woo |
| Christopher Meyer | Anton Gatewood |
| Ramon Rodriguez | Ben Cruz |
| Reagan Grella | Joanie |
| Savannah Grella | Joanie |
| Nicolette Robinson | Jane |
| Kaija Matiss | Mary-Kate Lockhart |
| Michael Godere | Caleb Lockhart |
| Richardson Cisneros-Jones | Nurse |
| Ana Tuazon Parsons | Ultrasound Technician |
| Dakota Shapiro | Isaac |
| Sophie Mae Reppert | Natalie |
| Paulina Alvarez | Gabrielle |
| Jojo Nwoko | Tarell |
| Katya MartÃn | Lily |
| Daniel Polo | Patrick |
| Jo Yang | Dr. Parry |
| Danny Fischer | Hal Lockhart |
| Lavinia Jones Wright | Lavinia |
| Natalie Roy | Jenny |
| Wendy Pearson | Athena's Friend |
| Quinn D'Andrea | A Cappella Singer |
| Alexandra Mountsier | A Cappella Singer |
| Elizabeth Brown | A Cappella Singer |
| Kaylah Sharve' Baker | A Cappella Singer |
| Elizabeth Gaba | A Cappella Singer |
| Devon Lawrence | A Cappella Singer |
| Tehillah Alphonso | A Cappella Singer |
| Rebecca Yim | A Cappella Singer |
| Nina Nelson | A Cappella Singer |
| Raul Roy Berrios Jr. | Hospital Visitor |
| Lauren Frandsen | Other Woman |