| Jared Padalecki | Sam Winchester |
| Jensen Ackles | Dean Winchester /
Demon Dean |
| Misha Collins | Castiel |
| Mark Sheppard | Crowley
(as Mark A. Sheppard) |
| Jim Beaver | Bobby Singer |
| Ruth Connell | Rowena MacLeod |
| Curtis Armstrong | Metatron |
| Richard Newman | Oliver Pryce |
| Fraser Corbett | Angelic Guard |
| Lee Majdoub | Hannah /
Guardian |
| Rowan Schlosberg | Nebbishy Demon |
| Steve Baran | Donnie |
| Chris McNally | Ty |
| Rhys Williams | Ty's Buddy #1 |
| Cyrus Bryant | Ty's Buddy #2
(as Cyrus Lord Bryant) |
| Virgil Davies | Bobby 1 |
| James Dreichel | Bobby 2
(as Jim Dreichel) |
| Andrew Green | Bobby 3 |
| Gary Sanghera | Bobby 4 |
| Michael Dickson | Mel
(uncredited) |
| Caroll Spinney | Big Bird
(uncredited) |