| Charlie Hunnam | Jackson 'Jax' Teller |
| Katey Sagal | Gemma Teller Morrow |
| Mark Boone Junior | Robert 'Bobby Elvis' Munson
(credit only) |
| Dayton Callie | Wayne Unser |
| Kim Coates | Alexander 'Tig' Trager |
| Drea de Matteo | Wendy Case |
| Tommy Flanagan | Filip 'Chibs' Telford |
| David Labrava | Happy Lowman |
| Niko Nicotera | George 'Ratboy' Skogstrom |
| Theo Rossi | Juan Carlos 'Juice' Ortiz |
| Jimmy Smits | Nero Padilla |
| Robert Patrick | Les Packer |
| Michael Ornstein | Chuck 'Chucky' Marstein |
| Emilio Rivera | Marcus Alvarez |
| Marilyn Manson | Ron Tully |
| Rusty Coones | Rane Quinn |
| Mo McRae | Tyler Yost |
| Hayley McFarland | Brooke Putner |
| Jacob Vargas | Allesandro Montez |
| Reynaldo Gallegos | Fiasco
(as Rey Gallegos) |
| Olivia Burnette | Homeless Woman |
| Ivo Nandi | Oscar El Oso Ramos |
| Ron Yuan | Ryu Tom |
| Bob McCracken | Brendan Roarke |
| Hal Holbrook | Nate Madock |
| Michael Chiklis | Milo |
| Scott Anderson | Connor Malone |
| Tony Curran | Gaines |
| Charisma Carpenter | Carol |
| Jack Cameron White | Monroe |
| Kevin Gage | Hench |
| Jason Barry | Declan |
| Evan Londo | Abel |
| Ryder Londo | Abel |
| Alan O'Neill | Hugh |
| Vic Stagliano | Night White Guard |
| Nikea Gamby-Turner | Black Female Guard |
| Jay Horton | Niner #1
(uncredited) |
| Sophia Markov | Thomas Teller
(uncredited) |
| Victoria Markov | Thomas Teller
(uncredited) |
| Angie Stevenson | Crow Eater
(uncredited) |
| Chad Michael Ward | Aryan Brotherhood
(uncredited) |