| Charlie Hunnam | Jackson 'Jax' Teller |
| Katey Sagal | Gemma Teller Morrow |
| Mark Boone Junior | Robert 'Bobby Elvis' Munson |
| Dayton Callie | Wayne Unser |
| Kim Coates | Alexander 'Tig' Trager |
| Tommy Flanagan | Filip 'Chibs' Telford |
| Theo Rossi | Juan Carlos 'Juice' Ortiz |
| Maggie Siff | Dr. Tara Knowles Teller |
| Ron Perlman | Clarence 'Clay' Morrow
(credit only) |
| Jimmy Smits | Nero Padilla |
| CCH Pounder | Tyne Patterson |
| Drea de Matteo | Wendy Case |
| Michael Ornstein | Chuck 'Chucky' Marstein |
| David Labrava | Happy Lowman |
| Emilio Rivera | Marcus Alvarez |
| Winter Ave Zoli | Lyla Winston |
| Billy Brown | August Marks |
| Niko Nicotera | George 'Ratboy' Skogstrom |
| Rusty Coones | Rane Quinn |
| Jacob Vargas | Allesandro Montez |
| Douglas Bennett | Orlin West |
| Keone Young | Bohai Lin |
| Reynaldo Gallegos | Fiasco
(as Rey Gallegos) |
| Mo McRae | Tyler Yost |
| Jeff Howard | ATF Agent Bowman |
| Evan Londo | Abel |
| Ryder Londo | Abel |
| Scott Anderson | Connor Malone |
| Kevin Fry | Neil
(as Kevin Fry-Bowers) |
| Alan O'Neill | Hugh |
| Marlane Barnes | Sandy |
| Rootie J. Boyd | Patterson's Aide
(uncredited) |
| Sophia Markov | Thomas Teller 2nd
(uncredited) |
| Natalie Skyy | Kiki
(uncredited) |
| Scott Wilder | Irish Thug #2
(uncredited) |