| Charlie Hunnam | Jackson 'Jax' Teller |
| Katey Sagal | Gemma Teller Morrow |
| Mark Boone Junior | Robert 'Bobby Elvis' Munson |
| Dayton Callie | Wayne Unser |
| Kim Coates | Alexander 'Tig' Trager |
| Tommy Flanagan | Filip 'Chibs' Telford |
| Theo Rossi | Juan Carlos 'Juice' Ortiz |
| Maggie Siff | Dr. Tara Knowles Teller |
| Ron Perlman | Clarence 'Clay' Morrow
(credit only) |
| Jimmy Smits | Nero Padilla |
| CCH Pounder | Tyne Patterson |
| Peter Weller | Charles 'Charlie' Barosky |
| Drea de Matteo | Wendy Case |
| Rockmond Dunbar | Lieutenant Eli Roosevelt |
| Robin Weigert | Ally Lowen |
| Niko Nicotera | George 'Ratboy' Skogstrom |
| Reynaldo Gallegos | Fiasco
(as Rey Gallegos) |
| Rusty Coones | Rane Quinn |
| Jenny Gago | Gloria Rodriguez |
| Hugo Medina | Felipe |
| Evan Londo | Abel |
| Ryder Londo | Abel |
| Mario Perez | Gomes |
| Zelia Scott | Patterson's Aide |
| Mario Cortez | Lead Cop |
| Lindsay McGrail | Homeless Woman
(uncredited) |