| Charlie Hunnam | Jackson 'Jax' Teller |
| Katey Sagal | Gemma Teller Morrow |
| Mark Boone Junior | Robert 'Bobby Elvis' Munson |
| Dayton Callie | Wayne Unser |
| Kim Coates | Alexander 'Tig' Trager |
| Tommy Flanagan | Filip 'Chibs' Telford |
| Ryan Hurst | Harry 'Opie' Winston |
| William Lucking | Piermont 'Piney' Winston |
| Theo Rossi | Juan Carlos 'Juice' Ortiz |
| Maggie Siff | Dr. Tara Knowles |
| Ron Perlman | Clarence 'Clay' Morrow |
| Sonny Barger | Lenny 'The Pimp' Janowitz |
| Danny Trejo | Romero 'Romeo' Parada |
| Rockmond Dunbar | Lieutenant Eli Roosevelt |
| Ray McKinnon | Lincoln 'Linc' Potter |
| Michael Ornstein | Chuck 'Chucky' Marstein |
| Benito Martinez | Luis Torres |
| David Rees Snell | Agent Grad Nicholas |
| Tory Kittles | Laroy Wayne |
| David Labrava | Happy Lowman |
| Chris Reed | Philip 'Filthy Phil' Russell |
| Niko Nicotera | George 'Ratboy' Skogstrom |
| Wally Rudolph | Chris 'V-Lin' Von Lin |
| LaMonica Garrett | Deputy Sheriff Cane |
| Dominic Flores | E.R. Doctor |
| Kim McCulloch | Nurse #1 |
| Andrea Toldeo | Nurse #2 |
| Ella Allan | Baby Thomas Teller |
| Mia Allan | Baby Thomas Teller |