| Charlie Hunnam | Jackson 'Jax' Teller |
| Katey Sagal | Gemma Teller Morrow |
| Mark Boone Junior | Robert 'Bobby Elvis' Munson |
| Dayton Callie | Wayne Unser |
| Kim Coates | Alexander 'Tig' Trager |
| Tommy Flanagan | Filip 'Chibs' Telford |
| Ryan Hurst | Harry 'Opie' Winston |
| William Lucking | Piermont 'Piney' Winston |
| Theo Rossi | Juan Carlos 'Juice' Ortiz |
| Maggie Siff | Dr. Tara Knowles |
| Ron Perlman | Clarence 'Clay' Morrow |
| Rockmond Dunbar | Lieutenant Eli Roosevelt |
| Ray McKinnon | Lincoln 'Linc' Potter |
| Emilio Rivera | Marcus Alvarez |
| Michael Ornstein | Chuck 'Chucky' Marstein
(as Michael Marisi Ornstein) |
| Winter Ave Zoli | Lyla Winston |
| Kristen Renton | Ima Tite |
| McNally Sagal | Margaret Murphy |
| Chris Reed | Philip 'Filthy Phil' Russell
(as Christopher Reed) |
| Wally Rudolph | V-Lin
(as Walter Wong) |
| Niko Nicotera | Rat Boy |
| Jesse Garcia | Rafi |
| Aldo Gonzalez | Pedro |
| David Fernandez Jr. | Driver |
| Cristela Alonzo | Latin Woman #1 |
| Cynthia Rose Hall | Latin Woman #2 |
| Tyler Silva | Abel |
| Ella Allan | Baby Thomas Teller
(uncredited) |
| Mia Allan | Baby Thomas Teller
(uncredited) |
| Damien Bray | Mayan #1
(uncredited) |
| Will Coffey | FBI Agent
(uncredited) |
| Roberto Garcia | Shooter #1
(uncredited) |
| Mario Perez | Shooter #2
(uncredited) |
| Christie Lynn Peterson | Club Girl
(uncredited) |