| Charlie Hunnam | Jackson 'Jax' Teller |
| Katey Sagal | Gemma Teller Morrow |
| Mark Boone Junior | Robert 'Bobby Elvis' Munson |
| Dayton Callie | Chief Wayne Unser |
| Kim Coates | Alexander 'Tig' Trager |
| Tommy Flanagan | Filip 'Chibs' Telford |
| Ryan Hurst | Harry 'Opie' Winston |
| William Lucking | Piermont 'Piney' Winston
(credit only) |
| Theo Rossi | Juan Carlos 'Juice' Ortiz |
| Maggie Siff | Dr. Tara Knowles |
| Ron Perlman | Clarence 'Clay' Morrow |
| Kenny Johnson | Herman Kozik |
| Mitch Pileggi | Ernest Darby |
| Paula Malcomson | Maureen Ashby |
| Titus Welliver | James 'Jimmy' O'Phelan |
| Winter Ave Zoli | Lyla Dvorak |
| Jeff Kober | Jacob Hale, Jr. |
| Michael Ornstein | Chuck 'Chucky' Marstein
(as Michael Marisi Ornstein) |
| Jose Pablo Cantillo | Hector Salazar |
| Zoe Boyle | Trinity Ashby |
| Andy McPhee | Keith 'McGee' McGee
(as Andrew McPhee) |
| Arie Verveen | Liam O'Neill |
| James Cosmo | Father Kellan Ashby |
| Leo Fitzpatrick | Shepard |
| Q'orianka Kilcher | Kerrianne Telford |
| Darin Heames | Seamus Ryan |
| Michael Fairman | Lumpy Feldstein |
| Dominic Keating | Luther Barkwill |
| Joel Tobeck | Donny |
| David Labrava | Happy Lowman |
| Bellina Logan | Fiona Larkin |
| McNally Sagal | Margaret Murphy |
| Lorcan O'Toole | Padraic Telford |
| Marya Delver | Officer Eglee |
| Frank Potter | Miles |
| Tara Macken | Luisa |
| Glenn Keogh | Michael Casey |
| Dan Hildebrand | Sean Casey |
| Dinah Lenney | Orphanage Nun |
| Robert Neary | PSNI Lieutenant |
| Jason McDonald | SOA Belfast Member #1 |
| Carla Jimenez | Clinic Admin |
| Matthew Alan | Mark |
| Lilly McDowell | Katey |
| Jason Castle | Irish Prospect
(uncredited) |
| David Dossett | SOA Belfast Member #1
(uncredited) |
| Christie Lynn Peterson | Club Girl
(uncredited) |