| Charlie Hunnam | Jackson 'Jax' Teller |
| Katey Sagal | Gemma Teller Morrow |
| Mark Boone Junior | Robert 'Bobby Elvis' Munson |
| Kim Coates | Alexander 'Tig' Trager |
| Tommy Flanagan | Filip 'Chibs' Telford |
| Ryan Hurst | Harry 'Opie' Winston |
| Johnny Lewis | Kip 'Half Sack' Epps |
| William Lucking | Piermont 'Piney' Winston |
| Theo Rossi | Juan Carlos 'Juice' Ortiz |
| Maggie Siff | Dr. Tara Knowles |
| Ron Perlman | Clarence 'Clay' Morrow |
| Ally Walker | Agent June Stahl |
| Adam Arkin | Ethan Zobelle |
| Taylor Sheridan | Deputy Chief David Hale
(as Tayler Sheridan) |
| Dayton Callie | Chief Wayne Unser |
| Tory Kittles | Laroy Wayne |
| Callard Harris | Edmond Hayes |
| Winter Ave Zoli | Lyla Dvorak |
| Sarah Jones | Polly Zobelle |
| Michael Ornstein | Chuck 'Chucky' Marstein
(as Michael Marisi Ornstein) |
| Henry Rollins | AJ Weston |
| Titus Welliver | James 'Jimmy' O'Phelan |
| Kenny Johnson | Herman Kozik |
| Kenneth Choi | Henry Lin |
| Marcos A. Ferraez | Agent Estevez
(as Marcos De La Cruz) |
| Julie Ariola | Mary Winston |
| Bellina Logan | Fiona Larkin |
| McNally Sagal | Margaret Murphy |
| Jason Matthew Smith | Ule |
| Adrian LaTourelle | Officer Craft |
| David Labrava | Happy |
| Lela Jane Cortines | Ellie Winston
(as Lela Cortines) |
| John Abendroth | Kenny Winston |
| Aaron Refvem | Cliff Weston
(as Aaron Revfem) |
| E.R. Ruiz | Gill
(as E.R) |
| Marya Delver | Officer Eglee |
| Trenton Rogers | Duke Weston |
| Kevin P. Kearns | Luke
(as Kevin Kearns) |
| Erika Ringor | CFS Agent |
| Russell B. McKenzie | ATF Agent |
| Joanie Ellen | Croweater |
| Samy Camara | Alison
(uncredited) |
| Les Mumphrey | Niner
(uncredited) |
| Alistair Steel | San Joaquin Sheriff
(uncredited) |