| Charlie Hunnam | Jackson 'Jax' Teller |
| Katey Sagal | Gemma Teller Morrow |
| Mark Boone Junior | Robert 'Bobby Elvis' Munson |
| Kim Coates | Alexander 'Tig' Trager |
| Tommy Flanagan | Filip 'Chibs' Telford |
| Johnny Lewis | Kip 'Half Sack' Epps
(credit only) |
| Maggie Siff | Dr. Tara Knowles |
| Ron Perlman | Clarence 'Clay' Morrow |
| Ryan Hurst | Harry 'Opie' Winston |
| Theo Rossi | Juan Carlos 'Juice' Ortiz |
| William Lucking | Piermont 'Piney' Winston |
| Taylor Sheridan | Deputy Chief David Hale
(as Tayler Sheridan) |
| Mitch Pileggi | Ernest Darby |
| Sprague Grayden | Donna Winston |
| Dayton Callie | Chief Wayne Unser |
| Emilio Rivera | Marcus Alvarez |
| Jamie McShane | Cameron Hayes |
| Kevin Alejandro | Esai Alvarez |
| David Labrava | Happy Lowman |
| Adrian LaTourelle | Officer Craft
(as Adrian La Tourelle) |
| Jay Karnes | Agent Joshua Kohn |
| Nicholas Guest | The Voice of John Teller
(voice) (as Nick Guest) |
| Lyle Kanouse | Brenan Hefner |
| Ashley Monique Clark | Female Witness |
| Iliana Fischer | Bobby's Girlfriend
(uncredited) |