| Charlie Hunnam | Jackson 'Jax' Teller |
| Katey Sagal | Gemma Teller Morrow |
| Mark Boone Junior | Robert 'Bobby Elvis' Munson |
| Kim Coates | Alexander 'Tig' Trager |
| Tommy Flanagan | Filip 'Chibs' Telford |
| Johnny Lewis | Kip 'Half Sack' Epps |
| Maggie Siff | Dr. Tara Knowles |
| Ron Perlman | Clarence 'Clay' Morrow |
| Drea de Matteo | Wendy Case |
| Theo Rossi | Juan Carlos 'Juice' Ortiz |
| Taylor Sheridan | Deputy Chief David Hale
(as Tayler Sheridan) |
| Mitch Pileggi | Ernest Darby |
| Dayton Callie | Chief Wayne Unser |
| Patrick St. Esprit | Elliott Oswald |
| Judith Hoag | Karen Oswald |
| Liana Liberato | Tristen Oswald |
| Kevin Chapman | Michael McKeavey |
| Jim Cody Williams | Uncle Vinky |
| James Carraway | Floyd |
| Jay Karnes | Agent Joshua Kohn |
| Nicholas Guest | The Voice of John Teller
(voice) (as Nick Guest) |
| Bobby Reed | Pastor
(as Bobby Charles Reed) |
| Frank Noon | Fat Clown |
| Walter Addison | Jacob Hale |
| Steve Kramer | Leo Kessler |
| Pablo Espinosa | Officer Fain |
| Brett Wagner | Johnny Yates |
| Karen Lew | Nurse |
| Brandon P Bell | ATF Administrator
(as Brandon Bell) |
| Kelly LaMarr | Customs Official |
| Paul Vroom | White Guy #1 |
| Holly Sherman | Teenage Tara Knowles
(uncredited) |
| Robyn Jean Springer | Crow-Eater Biker Chick
(uncredited) |
| Nick Wall | Biker
(uncredited) |