| Peter Krause | Nate Fisher |
| Michael C. Hall | David Fisher |
| Frances Conroy | Ruth Fisher |
| Lauren Ambrose | Claire Fisher |
| Freddy Rodríguez | Federico 'Rico' Diaz |
| Mathew St. Patrick | Keith Charles |
| Justina Machado | Vanessa Diaz |
| James Cromwell | George Sibley |
| Rachel Griffiths | Brenda Chenowith |
| Jeremy Sisto | Billy Chenowith |
| Joanna Cassidy | Margaret Chenowith |
| Tina Holmes | Maggie Sibley |
| Jennifer Elise Cox | Mary |
| C.J. Sanders | Anthony |
| Lisa Banes | Victoria |
| Rosalind Chao | Cindy |
| Mia Wesley | Frankie's Mom |
| Meagen Fay | Social Worker |
| Jayne Taini | Vera |
| Mary Gillis | Gerty |
| Ron Dean | Karl Holzenchenko |
| Danny Goldring | Augie Holzenchenko |
| Jack Wallace | Danny Holzenchenko |
| Andy Milder | Julio's Principal |
| Patty Tobin | Carmen |
| Drake Johnston | Danny's Nephew |
| Braeden Lemasters | Frankie
(as Braeden Le Masters) |
| Giancarlo Rodriguez | Julio Diaz |
| Brenna Tosh | Maya Fisher |
| Bronwyn Tosh | Maya Fisher |
| Lalonie Davis | Girl
(uncredited) |
| Audrey Harris | Knitting Student
(uncredited) |
| Sarah Nanko | Angelique
(uncredited) |
| Shea Weaver | Danny's Niece
(uncredited) |