| Peter Krause | Nate Fisher |
| Michael C. Hall | David Fisher |
| Frances Conroy | Ruth Fisher |
| Lauren Ambrose | Claire Fisher |
| Freddy Rodríguez | Federico 'Rico' Diaz |
| Mathew St. Patrick | Keith Charles |
| Rachel Griffiths | Brenda Chenowith |
| Lili Taylor | Lisa Kimmel |
| Jeremy Sisto | Billy Chenowith |
| Joanna Cassidy | Margaret Chenowith |
| Robert Foxworth | Dr. Bernard Chenowith |
| Glenn Fitzgerald | Aaron Buchbinder |
| Richard Jenkins | Nathaniel Fisher |
| Ed O'Ross | Nikolai |
| Justina Machado | Vanessa Diaz |
| Aysia Polk | Taylor |
| David Norona | Gary Deitman
(as David Noroña) |
| Efrain Figueroa | Andrew Perez |
| Eric Bruskotter | Keith's Partner |
| Gina Morelli | Leticia Perez |
| Vincent Castellanos | Beauty Parlor Owner |
| Jennie Vaughn | Abused Wife |
| Karl Makinen | Abusive Husband |
| Travis Wester | Henry |
| Diana Castle | Trust Lawyer |
| Jim Abele | Social Worker |
| Austin Nichols | Kyle |
| Richard Lynch | Commitment Ceremony Presider |
| Michael Dempsey | Sgt. Potts
(as Michael E. Dempsey) |
| Michael Khmurov | Russian Man in Line |
| Fred Blanco | Mauricio Diaz
(uncredited) |