| Peter Krause | Nate Fisher |
| Michael C. Hall | David Fisher |
| Frances Conroy | Ruth Fisher |
| Lauren Ambrose | Claire Fisher |
| Freddy Rodríguez | Federico 'Rico' Diaz |
| Mathew St. Patrick | Keith Charles |
| Rachel Griffiths | Brenda Chenowith |
| Glenn Fitzgerald | Aaron Buchbinder |
| Molly Parker | Rabbi Ari |
| Harriet Sansom Harris | Catherine Collins |
| Ed O'Ross | Nikolai |
| Justina Machado | Vanessa Diaz |
| Julie White | Mitzi Dalton Huntley |
| Joel Brooks | Robbie |
| Aysia Polk | Taylor |
| David Norona | Gary Deitman
(as David Noroña) |
| Marina Black | Parker McKenna |
| Nicki Micheaux | Karla |
| James Pickens Jr. | Roderick Charles |
| Beverly Todd | Lucille Charles |
| Ilia Volok | Yuri |
| Kim Coles | Dolores |
| Lynda Scarlino | Edith Kirky |
| Wilda Taylor | Ramona Kippleman |
| Jessica D. Stone | Young Brenda |
| Peter Birkenhead | David's Lawyer |
| Bruce Wright | Detective |
| Michael Childers | Coroner |
| Austin Nichols | Tall Stoner |
| Chase Penny | Short Stoner |
| Anthony Sherritt | Summons Server |
| Amy Wieczorek | Party Guest |
| Thomas Garner | Party Guest |
| Joanna Cassidy | Margaret Chenowith
(voice) (uncredited) |
| Robert Foxworth | Dr. Bernard Chenowith
(voice) (uncredited) |
| Adrienne Frantz | Soap Actress
(uncredited) |
| Ronn Moss | Soap Actor
(uncredited) |
| Justin Torkildsen | Soap Actror
(uncredited) |