| Peter Krause | Nate Fisher |
| Michael C. Hall | David Fisher |
| Frances Conroy | Ruth Fisher |
| Lauren Ambrose | Claire Fisher |
| Freddy Rodríguez | Federico 'Rico' Diaz |
| Mathew St. Patrick | Keith Charles |
| Rachel Griffiths | Brenda Chenowith |
| Mare Winningham | Eileen Piper |
| Richard Jenkins | Nathaniel Fisher |
| Eric Balfour | Gabe Dimas |
| Alice Krige | Alma |
| Grant Show | Scott Axelrod |
| Nan Martin | Rita Piper |
| Joel Brooks | Robbie |
| David Andrews | Michael Piper |
| Beverly Todd | Lucille Charles |
| Graham Jarvis | Bobo |
| David Norona | Gary Deitman
(as David Noroña) |
| Aysia Polk | Taylor |
| Kristopher Logan | Jack |
| Jerry Hauck | Stan |
| Romy Rosemont | Professor |
| Michael Bofshever | Minister |
| Luck Hari | Tahira |
| Raymond O'Connor | Man on Phone |
| Kyra Groves | Nurse |
| Amy Wheaton | Female Student |
| Benjamin John Parrillo | Plan Man
(as Ben Parrillo) |
| Herschel Bleefeld | Male Student |
| Barbara Gruen | Plan Woman 1 |
| Bree Michael Warner | Plan Woman 2 (Hipster Girl) |
| Greg Shamie | Guy in Car |
| Joe Camareno | Guidance Counselor |
| Ric McCloud | Man on Phone #2
(uncredited) |