| Peter Krause | Nate Fisher |
| Michael C. Hall | David Fisher |
| Frances Conroy | Ruth Fisher |
| Lauren Ambrose | Claire Fisher |
| Freddy Rodríguez | Federico 'Rico' Diaz
(as Freddy Rodriguez) |
| Mathew St. Patrick | Keith Charles |
| Rachel Griffiths | Brenda Chenowith |
| Ed Begley Jr. | Hiram Gunderson |
| Richard Jenkins | Nathaniel Fisher |
| Tracy Middendorf | Adele Swanson |
| Missy Yager | Jennifer Mason |
| Mark Devine | Chandler Swanson |
| Eric Balfour | Gabe Dimas |
| Gary Hershberger | Matthew Gilardi |
| Justina Machado | Vanessa Diaz |
| Daniel Zacapa | Mr. Suarez, Jr. |
| Maximillian Kesmodel | Young David
(as Maximillian Orion Kesmodel) |
| Richard Penn | Attorney |
| Melissa Egan | Debbie |
| Chip O'Neil | Ronnie |
| Van Epperson | Angry Man |
| Ralph Kampshoff | Mr. Bloomburg
(uncredited) |
| Hayden Tank | Young Nate
(archive footage) (uncredited) |